This study has investigated the effect of using the Uncaria tomentosa (UT) extract against immunotoxicity that induced by fipronil (FP) in male Wistar rats.Twenty-eight, male Wistar rats were assigned Lint Filter Seal randomly into four groups (7 rats each).Control group received distilled water.
FP group received FP 9.7 mg/kg b.wt orally via gastric tube.
UT group received 120 mg/kg b.wt.of UT extract orally.
FP-UT group received both FP and UT (9.7 and 120 mg/kg b.wt, respectively) for 30 days.
Hematological parameters, malondialdehyde (MDA), total antioxidant capacity (TAC), estradiol, histamine and immunoglobulin E (IGE) were assayed.Histopathological and electron microscopical examinations were performed to the lymphoid organs.Hematological parameters, were decreased in the FP group than the control group.
There was a rise in MDA of FP group followed by a TRAY decrease in TAC content with histological and ultrastructure degenerative changes.UT extract treatment ameliorated the FP-induced perturbations for the former parameters.The results showed that FP treatment exerted an immunotoxic effect through acting as an endocrine disruptor and allergic, pro-inflammatory that was confirmed by histopathological and ultrastructure study of the lymphoid organs.
Uncaria tomentosa extract could successfully modulate FP-induced immunotoxicity by diminishing all the studied parameters.